Glucophage (Metformin) 500mg / Strip
$2.25
Glucophage is a biguanide oral anti-hyperglycaemic agent. Its mode of action is thought to be multifactorial and includes delayed uptake of glucose from the gastrointestinal tract, increased peripheral glucose utilisation mediated by increased insulin sensitivity, and inhibition of increased hepatic and renal gluconeogenesis. No hypoglycaemia occurs when Glucophage is used alone but can occur when given concomitantly with a sulphonylurea, insulin or alcohol.
(In Stock)
Glucophage (Metformin) 500 mg Tablets
GLUCOPHAGE 850 mg Tablets
SCHEDULING STATUS:
S3
PROPRIETARY NAME
(and dosage form):
GLUCOPHAGE 500 mg Tablets
GLUCOPHAGE 850 mg Tablets
COMPOSITION:
Each Glucophage 500 mg Tablet contains 500 mg Metformin Hydrochloride.
Each Glucophage 850 mg Tablet contains 850 mg Metformin Hydrochloride.
PHARMACOLOGICAL CLASSIFICATION:
A 21.2 – Oral Hypoglycaemic.
PHARMACOLOGICAL ACTION:
Glucophage is a biguanide oral anti-hyperglycaemic agent.
INDICATIONS:
Non-insulin dependent diabetes when diet has failed and especially if the patient is overweight.
CONTRA-INDICATIONS:
Sensitivity to metformin hydrochloride. Diabetic coma and ketoacidosis, impairment of renal function, chronic liver disease, cardiac failure and recent myocardial infarction. History of, or states associated with, lactic acidosis such as shock or pulmonary insufficiency, alcoholism (acute or chronic), and conditions associated with hypoxemia. Pancreatitis.There is no information available concerning the safety of Glucophage during lactation.
WARNINGS:
Sensitivity to metformin hydrochloride. Diabetic coma and ketoacidosis, impairment of renal function, chronic liver disease, cardiac failure and recent myocardial infarction. History of, or states associated with, lactic acidosis such as shock or pulmonary insufficiency, alcoholism (acute or chronic), and conditions associated with hypoxemia. Pancreatitis. The use of Glucophage during pregnancy is not advised. There is no information available concerning the safety of Glucophage during lactation.
DOSAGE AND DIRECTIONS FOR USE:
It is important that Glucophage tablets be taken in divided doses with meals.
Adults:
Initially, one 850 mg tablet twice a day or one 500 mg tablet three times a day, with or after food. If control is incomplete a cautious increase in dosage to a maximum of 3 g daily is justified.
Children:
Glucophage is not recommended for use.
Elderly:
Glucophage is indicated in the elderly, but not when renal function is impaired.
Combination therapy – see “Special Precautions”
SIDE-EFFECTS AND SPECIAL PRECAUTIONS:
Gastro-intestinal adverse effects with anorexia, nausea and vomiting. Metallic taste.
Patients receiving continuous Glucophage therapy should have an annual estimation of Vitamin B12 levels because of reports of decreased Vitamin B12 absorption.
An interaction between Glucophage and anticoagulants is a possibility and dosage of the latter may need adjustment.
Contra-indications should be carefully observed.
KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT:
Hypoglycaemia can occur when Glucophage is given concomitantly with a sulphonylurea, insulin or alcohol. In excessive dosage, and particularly if there is a possibility of accumulation, lactic acidosis may develop.
IDENTIFICATION:
Glucophage 500 mg Tablets – White, round, biconvex, film-coated tablets.
Glucophage 850 mg Tablets – White, round shallow, biconvex film-coated tablets.
PRESENTATION:
Glucophage 500 mg Tablets 500 mg – 100’s and 500’s
Glucophage 850 mg Tablets 850 mg – 60’s and 300’s
STORAGE INSTRUCTIONS:
Store below 25°C. Protect from light and moisture.
Keep out of reach of children.
REGISTRATION NUMBER:
Glucophage 500 mg Tablets G3244 (Act 101/1965)
Glucophage 850 mg Tablets F/21.2/145
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